The first large-scale installations in space may very well be farms. By utilizing the vast emptiness of space, we could construct hundreds or thousands of farming installations and feed potentially billions of more people. The farms could either be automated or worked by astronauts in the ISS. In the latter case, the living quarters would have to be greatly expanded.
Plants don't really give a darn how much radiation shielding they get, so this could be cut to save money spent on installation construction.
The problem about need for many seeds can be eliminated by mass-cloning plant embryos in laboratories, from a single seed. It would then be unneccessary to bring many identical seeds. It would still be good to bring several seeds for genetic diversity, but that would be nowhere near the volumes of seeds needed in normal seeding.
The easiest way to send food to Earth would be to seal large shipments of food it in spherical capsules about the size of attack pods seen on Dragon Ball Z and just drop it onto Earth like a meteorite. Some form of parachutes would be needed to avoid destroying the food however, but that can be easily added to the construction.
Although we make enough food every single year to feed everyone in the world, some people die of starvation while others die from obesity-related diseases. Since such demonstrative property-assertion is a direct consequence of rivalry over scarce resources on overpopulated Earth, the only other way to feed the starving Africans and Indian children is to just make more food and give it to them.
Dropping food capsules into India and Africa every couple of weeks could remedy the starvation situation and relieve efforts to farm the unfarmable land, which will help stop the catastrophic erosion going on in those regions.
If we made farmed in space we also wouldn't have to ship food from Earth to the space station or other space colonies.
One important effect of food from space to poor families would be to eradicate their need to breed many children for agricultural workforce, which would help create zero population growth. Silly space colonization opponents often complain that spacelaunches would be unable to keep up with population increase, but in this way, space colonies would first help stabilize population on Earth, before the final launch-based decompression that eventually ends overpopulation forever. See also grand rescue.
Other help articles can be delivered as well, such as clothes, easily assembled dwellings such as well-insulated tents, warming fuel and medicines. In the case of medicines, the problem with analphabets unable to read instructions can be helped by recorded voices in the local language.